Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.

Cell death and differentiation - 1 Feb 2004

Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R

Abstract excerpt

Omi/HtrA2 is a mitochondrial serine protease that is released into the cytosol during apoptosis and promotes cytochrome c (Cyt c)dependent caspase activation by neutralizing inhibitor of apoptosis proteins (IAPs) via its IAP-binding motif. The protease activity of Omi/HtrA2 also contributes to the progression of both apoptosis and caspase-independent cell death. In this study, we found that wild-type Omi/HtrA2 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to Complement System Proteins
Share to Cytochromes c

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Intracellular Membranes

Share to Mitochondrial Proteins

Share to Serine Endopeptidases

Share to X-Linked Inhibitor of Apoptosis Protein

Source

Identifiers

PMID: 14605674
DOI: 10.1038/sj.cdd.4401343

Genes

XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.PMID 14605674Read ↗

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.Semantic proximity Read ↗

Progress in research on the role of Omi/HtrA2 in neurological diseasesSemantic proximity Read ↗

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagySemantic proximity Read ↗

The mitochondrial serine protease HtrA2/Omi: an overviewSemantic proximity Read ↗

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.Semantic proximity Read ↗

Life's smile, death's grin: vital functions of apoptosis-executing proteins.Semantic proximity Read ↗

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.Semantic proximity Read ↗

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomesSemantic proximity Read ↗

The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell deathSemantic proximity Read ↗

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: maintenance of mitochondrial homeostasis and induction of apoptosis like cell death under cellular stressSemantic proximity Read ↗

The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis.Semantic proximity Read ↗

HtrA Protease Family as Therapeutic TargetsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.