Article
Integrated Genomic Characterization of the Human Immunome in Cancer.
Cancer research - 1 Nov 2020
Li Yongsheng, Burgman Brandon, McGrail Daniel J, Sun Ming, Qi Dan, Shukla Sachet A, Wu Erxi, Capasso Anna, Lin Shiaw-Yih, Wu Catherine J, Eckhardt S Gail, Mills Gordon B, Li Bo, Sahni Nidhi, Yi S Stephen
Abstract excerpt
Alterations in immune-related pathways are common hallmarks of cancer. A comprehensive understanding of how cancer mutations rewire immune signaling networks and functional output across cancer types is instrumental to realize the full potential of immunotherapy. Here, we systematically interrogated somatic mutations involved in immune signaling that alter immune responses in patients with cancer. To do so, we...
Topics
- Algorithms
- Gene Regulatory Networks
- Genomics
- Humans
- Immunotherapy
- Mutation
- Neoplasms
- Transcriptome