Article
Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.
PloS one - 15 Mar 2011
Emmanuel Catherine, Gava Natalie, Kennedy Catherine, Balleine Rosemary L, Sharma Raghwa, Wain Gerard, Brand Alison, Hogg Russell, Etemadmoghadam Dariush, George Joshy, Birrer Michael J, Clarke Christine L, Chenevix-Trench Georgia, Bowtell David D L, Harnett Paul R, deFazio Anna
Abstract excerpt
Molecular events leading to epithelial ovarian cancer are poorly understood but ovulatory hormones and a high number of life-time ovulations with concomitant proliferation, apoptosis, and inflammation, increases risk. We identified genes that are regulated during the estrous cycle in murine ovarian surface epithelium and analysed these profiles to identify genes dysregulated in human ovarian cancer, using...
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