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Article

IGF-axis confers transformation and regeneration of fallopian tube fimbria epithelium upon ovulation

1 Mar 2019

Abstract excerpt

BACKGROUND: The fallopian tube fimbria is regarded as the main tissue of origin and incessant ovulation as the main risk factor of ovarian high-grade serous carcinoma. Previously, we discovered the tumorigenesis activity of human ovulatory follicular fluid (FF) upon injection to the mammary fat pad of Trp53-null mice. We also found a mutagenesis activity of FF-ROS and a apoptosis-rescuing activity of Hb from...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 30852161
DOI: 10.1016/j.ebiom.2019.01.061

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