Article
Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis.
The EMBO journal - 18 Oct 2006
Fink Gero, Schuchardt Isabel, Colombelli Julien, Stelzer Ernst, Steinberg Gero
Abstract excerpt
Spindle elongation segregates chromosomes and occurs in anaphase, an essential step in mitosis. Dynein-mediated pulling forces position the spindle, but their role in anaphase is a matter of debate. Here, we demonstrate that dynein is responsible for rapid spindle elongation in the model fungus Ustilago maydis. We show that initial slow elongation is supported by kinesin-5, which is located in the spindle...
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