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Article

XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract.

Molecular biology of the cell - 1 Jun 2009

Kronja Iva, Kruljac-Letunic Anamarija, Caudron-Herger Maïwen, Bieling Peter, Karsenti Eric

Abstract excerpt

In metaphase Xenopus egg extracts, global microtubule growth is mainly promoted by two unrelated microtubule stabilizers, end-binding protein 1 (EB1) and XMAP215. Here, we explore their role and potential redundancy in the regulation of spindle assembly and function. We find that at physiological expression levels, both proteins are required for proper spindle architecture: Spindles assembled in the absence of...

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Identifiers

PMID: 19369422
DOI: 10.1091/mbc.e08-10-1051
PMCID: PMC2688548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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