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Article

Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction.

Cardiovascular research - 1 Oct 2018

Lörchner Holger, Hou Yunlong, Adrian-Segarra Juan M, Kulhei Jennifer, Detzer Julia, Günther Stefan, Gajawada Praveen, Warnecke Henning, Niessen Hans W, Pöling Jochen, Braun Thomas

Abstract excerpt

Aims: Myocardial infarction (MI) causes a massive increase of macrophages in the heart, which serve various non-redundant functions for cardiac repair. The identities of signals controlling recruitment of functionally distinct cardiac macrophages to sites of injury are only partially known. Previous work identified Regenerating islet-derived protein 3 beta (Reg3β) as a novel factor directing macrophages to sites...

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PMID: 29850784
DOI: 10.1093/cvr/cvy126

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