Article
Mapping macrophage polarization over the myocardial infarction time continuum.
Basic research in cardiology - 4 Jun 2018
Mouton Alan J, DeLeon-Pennell Kristine Y, Rivera Gonzalez Osvaldo J, Flynn Elizabeth R, Freeman Tom C, Saucerman Jeffrey J, Garrett Michael R, Ma Yonggang, Harmancey Romain, Lindsey Merry L
Abstract excerpt
In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and scar formation. We hypothesized that macrophages undergo polarization state changes over the MI time course and assessed macrophage polarization transcriptomic signatures over the first week of MI. C57BL/6 J male mice (3-6 months old) were subjected to permanent coronary artery ligation to induce MI, and macrophages were...
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