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Article

CD226 deletion improves post-infarction healing via modulating macrophage polarization in mice.

Theranostics - 1 Jan 2020

Li Jun, Song Yun, Jin Jing-Yi, Li Guo-Hua, Guo Yong-Zheng, Yi Hong-Yu, Zhang Jin-Rui, Lu Ya-Jie, Zhang Jing-Long, Li Cong-Ye, Gao Chao, Yang Lu, Fu Feng, Chen Fu-Lin, Zhang Shu-Miao, Jia Min, Zheng Guo-Xu, Pei Jian-Ming, Chen Li-Hua

Abstract excerpt

Macrophages are essential for wound repair after myocardial infarction (MI). CD226, a member of immunoglobulin superfamily, is expressed on inflammatory monocytes, however, the role of CD226 in infarct healing and the effect of CD226 on macrophage remain unknown. Methods: Wild type and CD226 knockout (CD226 KO) mice were subjected to permanent coronary ligation. CD226 expression, cardiac function and ventricular...

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Share to Antigens, Differentiation, T-Lymphocyte
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocardial Infarction

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Source

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Identifiers

PMID: 32104514
DOI: 10.7150/thno.37106
PMCID: PMC7019150

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