Transcriptome-Wide Association Study Identifies Susceptibility Loci and Genes for Age at Natural Menopause.

doi:10.1177/1933719118776788

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Article

Transcriptome-Wide Association Study Identifies Susceptibility Loci and Genes for Age at Natural Menopause.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2019

Shi Jiajun, Wu Lang, Li Bingshan, Lu Yingchang, Guo Xingyi, Cai Qiuyin, Long Jirong, Wen Wanqing, Zheng Wei, Shu Xiao-Ou

Abstract excerpt

OBJECTIVE: To identify novel susceptibility genes for age at natural menopause (ANM). METHODS: Using transcription data generated in tissues from normal hypothalami (n = 73) and ovaries (n = 68) and high-density genotyping data provided by the Genotype-Tissue Expression (GTEx) database, we built 16 164 genetic models to predict gene expression across the transcriptome in these tissues. We used these models and...

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Identifiers

PMID: 29848177
DOI: 10.1177/1933719118776788
PMCID: PMC6421625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.