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Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses

22 Nov 2024

Abstract excerpt

The ovary is the first organ to age in the human body, affecting both fertility and overall health. However, the biological mechanisms underlying human ovarian aging remain poorly understood. Here we present a comprehensive single-nuclei multi-omics atlas of four young (ages 23–29 years) and four reproductively aged (ages 49–54 years) human ovaries. Our analyses reveal coordinated changes in transcriptomes and...

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PMID: 39578560
DOI: 10.1038/s43587-024-00762-5

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