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Article

Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2.

American journal of physiology. Cell physiology - 1 Apr 2009

Xiao Qingzhong, Luo Zhenling, Pepe Anna Elena, Margariti Andriani, Zeng Lingfang, Xu Qingbo

Abstract excerpt

NADPH oxidase (Nox4) produces reactive oxygen species (ROS) that are important for vascular smooth muscle cell (SMC) behavior, but the potential impact of Nox4 in stem cell differentiation is unknown. When mouse embryonic stem (ES) cells were plated on collagen IV-coated dishes/flasks, a panel of SMC-specific genes was significantly and consistently upregulated. Nox4 expression was markedly correlated with such a...

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Source

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PMID: 19036941
DOI: 10.1152/ajpcell.00442.2008

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SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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