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Article

High fluid shear stress prevents atherosclerotic plaque formation by promoting endothelium denudation and synthetic phenotype of vascular smooth muscle cells.

Molecular medicine reports - 1 Aug 2021

Wang Juan, Wang Yan, Sheng Lin, He Tian, Nin Xiang, Xue Aiying, Zhang Hua, Liu Zhendong

Abstract excerpt

Low blood fluid shear stress (SS) promotes vascular remodeling and atherosclerosis; however, the effects of high (H)SS on vascular remodeling and atherogenesis is not fully clarified. The major goal of this study was to investigate the role of HSS in atherosclerotic plaque formation. A perivascular SS modifier was implanted in the right carotid artery of apolipoprotein E (ApoE)‑/‑ mice to induce HSS, whereas the...

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Topics

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Share to Carotid Arteries
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Matrix Metalloproteinase 8

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Stress, Mechanical

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 34132364
DOI: 10.3892/mmr.2021.12216
PMCID: PMC8223103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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