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Article

Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice.

Scientific reports - 29 May 2018

Dominguez Sara L, Hegde Ganapati V, Hanson Jesse E, Xiang Hong, Mandikian Danielle, Boswell C Andrew, Chiu Cecilia, Wu Yan, Tsai Siao Ping, Fleck Daniel, Weber Martin, Ngu Hai, Scearce-Levie Kimberly, Jackson Erica L

Abstract excerpt

Neuregulin 1 (NRG1) is required for development of the central and peripheral nervous system and regulates neurotransmission in the adult. NRG1 and the gene encoding its receptor, ERBB4, are risk genes for schizophrenia, although how alterations in these genes disrupt their function has not been fully established. Studies of knockout and transgenic mice have yielded conflicting results, with both gain and loss of...

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Source

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Identifiers

PMID: 29844389
DOI: 10.1038/s41598-018-26492-4
PMCID: PMC5974084

Genes

NRG1
ERBB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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