Article
Neuregulins and neuronal plasticity: possible relevance in schizophrenia.
Novartis Foundation symposium - 1 Jan 2008
Buonanno Andrés, Kwon Oh-Bin, Yan Leqin, Gonzalez Carmen, Longart Marines, Hoffman Dax, Vullhorst Detlef
Abstract excerpt
Polymorphisms in the Neuregulin 1 (NRG1) and ErbB4 receptor genes have been associated with schizophrenia in numerous cohort and family studies, and biochemical measurements from postmortem prefrontal cortex homogenates suggest that NRG/ErbB signalling is altered in schizophrenia. Moreover, recent work from our group, and from others, indicates that NRG/ErbB signalling has a role in regulating glutamatergic...
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