Article
Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1.
Neuron - 22 May 2013
Yin Dong-Min, Chen Yong-Jun, Lu Yi-Sheng, Bean Jonathan C, Sathyamurthy Anupama, Shen Chengyong, Liu Xihui, Lin Thiri W, Smith Clifford A, Xiong Wen-Cheng, Mei Lin
Abstract excerpt
Neuregulin 1 (Nrg1) is a susceptibility gene of schizophrenia, a disabling mental illness that affects 1% of the general population. Here, we show that ctoNrg1 mice, which mimic high levels of NRG1 observed in forebrain regions of schizophrenic patients, exhibit behavioral deficits and hypofunction of glutamatergic and GABAergic pathways. Intriguingly, these deficits were diminished when NRG1 expression returned...
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