Article
Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood.
PloS one - 1 Jan 2014
Paterson Clare, Law Amanda J
Abstract excerpt
Neuregulin 3 (NRG3), a specific ligand for ErbB4 and a neuronal-enriched neurotrophin is implicated in the genetic predisposition to a broad spectrum of neurodevelopmental, neurocognitive and neuropsychiatric disorders, including Alzheimer's disease, autism and schizophrenia. Genetic studies in schizophrenia demonstrate that risk variants in NRG3 are associated with cognitive and psychotic symptom severity,...
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