Article
Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions.
Brain research - 19 Oct 2009
Ehrlichman Richard S, Luminais Steven N, White Samantha L, Rudnick Noam D, Ma Nan, Dow Holly C, Kreibich Arati S, Abel Ted, Brodkin Edward S, Hahn Chang-Gyu, Siegel Steven J
Abstract excerpt
INTRODUCTION: Neuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia and plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using mutant mice heterozygous for Nrg1 (Nrg1(+/-)) we studied the effects of Nrg1 signaling on behavioral and electrophysiological m...
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