Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.

Biological psychiatry - 15 Jul 2014

Luo Xiaoyang, He Wanxia, Hu Xiangyou, Yan Riqiang

Abstract excerpt

BACKGROUND: Neuregulin-1 (Nrg1) is a pleiotropic signaling molecule that regulates neural development, and mutation of Nrg1 is a risk factor for schizophrenia. Cleavage of type I β1 Nrg1 isoform by Bace1 releases a secreted N-terminal fragment (Nrg1-ntfβ), which can bind to a cognate ErbB receptor to activate the specific signaling cascade. This study aimed to determine whether increased expression of Nrg1 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Aspartic Acid Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Behavior, Animal

Share to Mice, Transgenic

Share to Neuregulin-1

Share to Receptors, Glutamate

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 24210810
DOI: 10.1016/j.biopsych.2013.09.026
PMCID: PMC3976896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.PMID 24210810Read ↗

Phenotypic characterization of transgenic mice overexpressing neuregulin-1.Semantic proximity Read ↗

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia ModelSemantic proximity Read ↗

Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in MiceSemantic proximity Read ↗

Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1.Semantic proximity Read ↗

Neuregulin-1 and schizophrenia in the genome-wide association study era.Semantic proximity Read ↗

Mechanisms of neuregulin action.Semantic proximity Read ↗

Neuregulin1 nuclear signaling influences adult neurogenesis and regulates a schizophrenia susceptibility gene network within the mouse dentate gyrusSemantic proximity Read ↗

Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus.Semantic proximity Read ↗

BACE1 Dependent Neuregulin Processing: ReviewSemantic proximity Read ↗

Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic PlasticitySemantic proximity Read ↗

Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophreniaSemantic proximity Read ↗

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.