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Article

Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Jan 2011

Ting Annie K, Chen Yongjun, Wen Lei, Yin Dong-Min, Shen Chengyong, Tao Yanmei, Liu Xihui, Xiong Wen-Cheng, Mei Lin

Abstract excerpt

Neuregulin 1 (NRG1) and its receptor ErbB4 are both susceptibility genes of schizophrenia. However, little is known about the underlying mechanisms of their malfunction. Although ErbB4 is enriched in GABAergic interneurons, the role of NRG1 in excitatory synapse formation in these neurons remains poorly understood. We showed that NRG1 increased both the number and size of PSD-95 puncta and the frequency and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21209185
DOI: 10.1523/JNEUROSCI.2538-10.2011
PMCID: PMC3078582

Genes

NRG1
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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