Article
Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in individuals exposed to Plasmodium vivax.
Scientific reports - 29 May 2018
Changrob Siriruk, McHenry Amy M, Nyunt Myat Htut, Sattabongkot Jetsumon, Han Eun-Taek, Adams John H, Chootong Patchanee
Abstract excerpt
The major challenge in designing a protective Duffy binding protein region II (DBPII)-based vaccine against blood-stage vivax malaria is the high number of polymorphisms in critical residues targeted by binding-inhibitory antibodies. Here, longevity of antibody and memory B cell response (MBCs) to DBL-TH variants, DBL-TH2, -TH4, -TH5, -TH6 and -TH9 were analyzed in P. vivax-exposed individuals living in a low...
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