Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in individuals exposed to Plasmodium vivax.

doi:10.1038/s41598-018-26677-x

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Article

Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in individuals exposed to Plasmodium vivax.

Scientific reports - 29 May 2018

Changrob Siriruk, McHenry Amy M, Nyunt Myat Htut, Sattabongkot Jetsumon, Han Eun-Taek, Adams John H, Chootong Patchanee

Abstract excerpt

The major challenge in designing a protective Duffy binding protein region II (DBPII)-based vaccine against blood-stage vivax malaria is the high number of polymorphisms in critical residues targeted by binding-inhibitory antibodies. Here, longevity of antibody and memory B cell response (MBCs) to DBL-TH variants, DBL-TH2, -TH4, -TH5, -TH6 and -TH9 were analyzed in P. vivax-exposed individuals living in a low...

Topics

Adult
Aged
Antibodies, Protozoan
Antibody Formation
B-Lymphocytes
Cohort Studies
Cross-Sectional Studies
Duffy Blood-Group System
Female
Humans
Immunity, Humoral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malaria

Malaria Vaccines

Malaria, Vivax

Male

Middle Aged

Phenotype

Plasmodium vivax

Source

Open in PubMed Open full text

Identifiers

PMID: 29844379
DOI: 10.1038/s41598-018-26677-x
PMCID: PMC5973932

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29844379-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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