Article
Non-allele specific antibody responses to genetically distinct variant forms of Plasmodium vivax Duffy binding protein (PvDBP-II) in Iranians exposed to seasonal malaria transmission.
Acta tropica - 1 Aug 2014
Valizadeh Vahideh, Zakeri Sedigheh, Mehrizi Akram Abouei, Djadid Navid Dinparast
Abstract excerpt
Duffy binding protein (DBP) is a leading vaccine candidate of Plasmodium vivax. The binding domain of DBP (DBP-II) is polymorphic, that may be a major challenge for development of a broadly effective vaccine against vivax malaria. The present investigation was undertaken to explore whether the se...
Topics
- Amino-Acid N-Acetyltransferase
- Animals
- Antibodies, Protozoan
- Antibody Specificity
- Antigens, Protozoan
- Epitopes, B-Lymphocyte
- Female
- Gene Expression Regulation
- Genetic Variation
- Humans
- Iran
- Malaria Vaccines
- Malaria, Vivax
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Plasmodium vivax
- Protozoan Proteins