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Article

Genetic diversity and neutral selection in Plasmodium vivax erythrocyte binding protein correlates with patient antigenicity.

PLoS neglected tropical diseases - 1 Jul 2020

Han Jin-Hee, Cho Jee-Sun, Ong Jessica J Y, Park Ji-Hoon, Nyunt Myat Htut, Sutanto Edwin, Trimarsanto Hidayat, Petros Beyene, Aseffa Abraham, Getachew Sisay, Sriprawat Kanlaya, Anstey Nicholas M, Grigg Matthew J, Barber Bridget E, William Timothy, Qi Gao, Liu Yaobao, Pearson Richard D, Auburn Sarah, Price Ric N, Nosten Francois, Rénia Laurent, Russell Bruce, Han Eun-Taek

Abstract excerpt

Plasmodium vivax is the most widespread and difficult to treat cause of human malaria. The development of vaccines against the blood stages of P. vivax remains a key objective for the control and elimination of vivax malaria. Erythrocyte binding-like (EBL) protein family members such as Duffy binding protein (PvDBP) are of critical importance to erythrocyte invasion and have been the major target for vivax...

Topics

Amino Acid Sequence
Antibodies, Protozoan
Asia
Genetic Variation
Humans
Immunity, Humoral
Malaria, Vivax
Plasmodium vivax

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Protozoan Proteins

Selection, Genetic

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 32645098
DOI: 10.1371/journal.pntd.0008202
PMCID: PMC7347095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32645098-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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