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Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein

3 Apr 2019

Abstract excerpt

Abstract Plasmodium vivax invasion of reticulocytes relies on distinct receptor-ligand interactions between the parasite and host erythrocytes. Engagement of the highly polymorphic domain II of the P. vivax Duffy-binding protein (DBPII) with the erythrocyte’s Duffy Ag receptor for chemokines (DARC) is essential. Some P. vivax–exposed individuals acquired Abs to DBPII that block DBPII-DARC interaction and inhibit...

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PMID: 30944159
DOI: 10.4049/jimmunol.1801631

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Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding ProteinPMID 30944159Read ↗

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