Article
The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants.
PLoS neglected tropical diseases - 1 Dec 2016
Kano Flora S, Souza-Silva Flávia A, Torres Leticia M, Lima Barbara A S, Sousa Taís N, Alves Jéssica R S, Rocha Roberto S, Fontes Cor J F, Sanchez Bruno A M, Adams John H, Brito Cristiana F A, Pires Douglas E V, Ascher David B, Sell Ana Maria, Carvalho Luzia H
Abstract excerpt
BACKGROUND: The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). A high proportion of P. vivax-exposed individuals fail to develop antibodies that inhibit DBPII-DARC interaction, and genetic factors that modulate this humoral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.