Article
Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2016
Chen Edwin, Salinas Nichole D, Huang Yining, Ntumngia Francis, Plasencia Manolo D, Gross Michael L, Adams John H, Tolia Niraj Harish
Abstract excerpt
Plasmodium vivax Duffy Binding Protein (PvDBP) is the most promising vaccine candidate for P. vivax malaria. The polymorphic nature of PvDBP induces strain-specific immune responses, however, and the epitopes of broadly neutralizing antibodies are unknown. These features hamper the rational design of potent DBP-based vaccines and necessitate the identification of globally conserved epitopes. Using X-ray...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antigens, Protozoan
- Crystallography, X-Ray
- Enzyme-Linked Immunosorbent Assay
- Epitopes, B-Lymphocyte
- Erythrocytes
- Genetic Variation