Worldwide genetic variability of the Duffy binding protein: insights into Plasmodium vivax vaccine development.

doi:10.1371/journal.pone.0022944

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Article

Worldwide genetic variability of the Duffy binding protein: insights into Plasmodium vivax vaccine development.

PloS one - 1 Jan 2011

Nóbrega de Sousa Taís, Carvalho Luzia Helena, Alves de Brito Cristiana Ferreira

Abstract excerpt

The dependence of Plasmodium vivax on invasion mediated by Duffy binding protein (DBP) makes this protein a prime candidate for development of a vaccine. However, the development of a DBP-based vaccine might be hampered by the high variability of the protein ligand (DBP(II)), known to bias the im...

Topics

Animals
Antigens, Protozoan
Bayes Theorem
Cluster Analysis
Genetic Variation
Haplotypes
Malaria Vaccines
Plasmodium vivax
Polymorphism, Genetic
Protozoan Proteins
Receptors, Cell Surface

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