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Article

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.

Nature medicine - 1 Jun 2010

Lee Sung Hee, Hu Li-Li, Gonzalez-Navajas Jose, Seo Geom Seog, Shen Carol, Brick Jonathan, Herdman Scott, Varki Nissi, Corr Maripat, Lee Jongdae, Raz Eyal

Abstract excerpt

Toll-like receptor (TLR) signaling is essential for intestinal tumorigenesis in Apc(min/+) mice, but the mechanisms by which Apc enhances tumor growth are unknown. Here we show that microflora-MyD88-ERK signaling in intestinal epithelial cells (IECs) promotes tumorigenesis by increasing the stability of the c-Myc oncoprotein. Activation of ERK (extracellular signal-related kinase) phosphorylates c-Myc, preventing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20473309
DOI: 10.1038/nm.2143
PMCID: PMC2882530

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.PMID 20473309Read ↗

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