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Article

MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer

6 Nov 2019

Abstract excerpt

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide and understanding its underlying molecular mechanisms is crucial for the development of therapeutic strategies. The mitogen-activated protein kinase-kinase 3 (MKK3) is a specific activator of p38 MAP kinases (p38 MAPKs), which contributes to the regulation of several cellular functions, such as proliferation, differentiation, apoptosis...

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PMID: 31695024
DOI: 10.1038/s41419-019-2083-2

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