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Article

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

5 May 2021

Abstract excerpt

Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33, that is often overexpressed in cancer. Nonetheless, regulatory factors that dictate ILC2 functions remain poorly studied. Here, we show that peroxisome proliferator-activated receptor gamma (PPARγ) is selectively expressed in...

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PMID: 33953160
DOI: 10.1038/s41467-021-22764-2

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