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Article

Genomic landscape of non-small-cell lung cancer with methylthioadenosine phosphorylase (MTAP) deficiency.

Cancer medicine - 1 Jan 2023

Ashok Kumar Prashanth, Graziano Stephen L, Danziger Natalie, Pavlick Dean, Severson Eric A, Ramkissoon Shakti H, Huang Richard S P, Decker Brennan, Ross Jeffrey S

Abstract excerpt

INTRODUCTION: New treatment strategies for advanced non-small-cell lung carcinoma (NSCLC) include synthetic lethality targets focused on protein arginine methyl transferases such as PRMT5 that exploit the impact of genomic loss of methylthioadenosine phosphorylase (MTAP). METHODS: Twenty nine thousand three hundred seventy nine advanced NSCLC cases underwent hybrid-capture based comprehensive genomic profiling...

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PMID: 35747993
DOI: 10.1002/cam4.4971
PMCID: PMC9883541

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