Prevalence of S-methyl-5'-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer: A Tissue Microarray Study on 13,067 Tumors From 149 Different Tumor Types.

doi:10.1097/PAS.0000000000002297

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Article

Prevalence of S-methyl-5'-thioadenosine Phosphorylase (MTAP) Deficiency in Human Cancer: A Tissue Microarray Study on 13,067 Tumors From 149 Different Tumor Types.

The American journal of surgical pathology - 1 Oct 2024

Gorbokon Natalia, Wößner Niklas, Lennartz Maximilian, Dwertmann Rico Sebastian, Kind Simon, Reiswich Viktor, Viehweger Florian, Lutz Florian, Fraune Christoph, Luebke Andreas M, Hube-Magg Claudia, Menz Anne, Schlichter Ria, Krech Till, Hinsch Andrea, Burandt Eike, Sauter Guido, Simon Ronald, Steurer Stefan, Marx Andreas H, Lebok Patrick, Dum David, Minner Sarah, Jacobsen Frank, Clauditz Till S, Hackert Thilo, Uzunoǧlu Faik G, Bubendorf Lukas, Bernreuther Christian, Kluth Martina

Abstract excerpt

Loss of S-methyl-5'-thioadenosine phosphorylase (MTAP) expression is a common event in cancer leading to a critical vulnerability of cancer cells towards anti-cancer drugs. Homozygous MTAP deletions result in a complete expression loss that can be detected by immunohistochemistry (IHC). In this study, a tissue microarray containing 17,078 samples from 149 different tumor entities was analyzed by IHC, and complete...

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PMID: 39132873
DOI: 10.1097/PAS.0000000000002297
PMCID: PMC11404761

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