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Methylthioadenosine Phosphorylase Genomic Loss in Advanced Gastrointestinal Cancers

1 Feb 2024

Abstract excerpt

BACKGROUND: One of the most common sporadic homozygous deletions in cancers is 9p21 loss, which includes the genes methylthioadenosine phosphorylase (MTAP), CDKN2A, and CDKN2B, and has been correlated with worsened outcomes and immunotherapy resistance. MTAP-loss is a developing drug target through synthetic lethality with MAT2A and PMRT5 inhibitors. The purpose of this study is to investigate the prevalence and...

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PMID: 38330461
DOI: 10.1093/oncolo/oyae011

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