Article
Comprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants.
Cancer letters - 1 Sept 2018
Kalu Nene N, Mazumdar Tuhina, Peng Shaohua, Tong Pan, Shen Li, Wang Jing, Banerjee Upasana, Myers Jeffrey N, Pickering Curtis R, Brunell David, Stephan Clifford C, Johnson Faye M
Abstract excerpt
To address the unmet need for effective biomarker-driven targeted therapy for human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) and cervical cancer, we conducted a high-throughput drug screen using 1122 compounds in 13 HPV-positive and 11 matched HPV-negative cell lines. The most effective drug classes were inhibitors of polo-like kinase, proteasomes, histone deacetylase, and...
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