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Article

Dual CDK and MEK Inhibition potentiates CD8+ T cell-mediated antitumor immunity by inducing pyroptotic cell death in high-mutational head and neck cancer.

Journal of experimental & clinical cancer research : CR - 6 Nov 2025

Chen Fanghui, Yang Fang, Popoola David O, Yang Jianqiang, Tang Chris, Payne Alexis, Zhang Lynn, Schmitt Nicole C, Xie Jin, Saba Nabil F, Li Yamin, Teng Yong

Abstract excerpt

BACKGROUND: HPV-negative (-) head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous cancer characterized by high mutational burden, an immunosuppressive microenvironment, and poor response to standard therapies. These features highlight the urgent need for novel and more effective treatment strategies. METHODS: Drug sensitivity prediction was performed using integrated datasets from TCGA, GDSC,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41194215
DOI: 10.1186/s13046-025-03557-7
PMCID: PMC12590917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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