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Article

NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents

8 Jul 2019

Abstract excerpt

BACKGROUND: Compared to HPV-negative head and neck squamous cell carcinomas (HNSCCs), HPV-positive HNSCCs are associated with a favorable prognosis in part due to their improved treatment sensitivity. Inactivating mutations in NSD1 were shown to be a favorable prognostic biomarker in laryngeal cancers. Here, we characterize NSD1 mutations from the expanded The Cancer Genome Atlas (TCGA) HNSCC cohort (n = 522) and...

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PMID: 31321084
DOI: 10.1186/s41199-019-0042-3

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