Article

Drug Repositioning for HPV Clade-Specific Cervicouterine Cancer Using the OCTAD Pipeline

2025-10-07

Abstract excerpt

Cervical cancer remains a major global burden largely driven by persistent infection with high-risk human papillomavirus (HPV). Biological diversity across HPV phylogenetic clades (α-7 and α-9) may shape tumor programs and outcomes. To accelerate therapeutic options, we implemented an expression based, clade informed drug repurposing pipeline using OCTAD. We built disease signatures for HPV-α7 and HPV-α9 tumors, r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd3ddedd-08b3-5eec-86ae-ea1574855abe
DOI: 10.20944/preprints202510.0320.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug Repositioning for HPV Clade-Specific Cervicouterine Cancer Using the OCTAD PipelineDOI 10.20944/preprints202510.0320.v1Read

Emerging Therapeutic Strategies for HPV-Related Cancers: From Gene Editing to Precision OncologySemantic proximity Read

Epigenetic and Genetic Keys to Fight HPV-Related CancersSemantic proximity Read

Integrated Patient-Derived Xenograft and Patient-Derived Cell Models Reveal Therapeutic Vulnerabilities Beyond Standard-of-Care Therapy in Endometrial CancerSemantic proximity Read

A comparative meta-genomic analysis of HPV strains: A step towards the design, synthesis and characterization of noval quenazoline derivative for antiviral activity.Semantic proximity Read

Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancerSemantic proximity Read

Comprehensive pharmacogenomic profiling of human papillomavirus-positive and -negative squamous cell carcinoma identifies sensitivity to aurora kinase inhibition in KMT2D mutants.Semantic proximity Read

Differential Transcriptomic Modulation by Histone Deacetylase Inhibitor SAHA in LUAD and LUSCSemantic proximity Read

HPV as a Molecular Hacker: How the Virus Hijacks Transcription Factors to Trigger CancerSemantic proximity Read

Histone Deacetylase Inhibitors as Therapeutic Interventions on Cervical Cancer Induced by Human PapillomavirusSemantic proximity Read

Phenotype-Oriented Characterization of NSC828786 Identifies Convergent HPN-AMACR-Associated Transcriptomic Signatures in Prostate Adenocarcinoma and Broad-Spectrum Antiproliferative Activity.Semantic proximity Read

Identification and Characterization of Small Molecule Human Papillomavirus E6 InhibitorsSemantic proximity Read

Two axes of drug transcriptional response, and a mechanistic correlate that organizes them: a conservation–divergence audit of Tahoe-100MSemantic proximity Read