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Article

Functional Precision Medicine Identifies Novel Druggable Targets and Therapeutic Options in Head and Neck Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2018

Xu Chang, Nikolova Olga, Basom Ryan S, Mitchell Ryan M, Shaw Reid, Moser Russell D, Park Heuijoon, Gurley Kay E, Kao Michael C, Green Carlos L, Schaub Franz X, Diaz Robert L, Swan Hallie A, Jang In S, Guinney Justin, Gadi Vijayakrishna K, Margolin Adam A, Grandori Carla, Kemp Christopher J, Méndez Eduardo

Abstract excerpt

Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with high mortality and a lack of targeted therapies. To identify and prioritize druggable targets, we performed genome analysis together with genome-scale siRNA and oncology drug profiling using low-passage tumor cells derived from a patient with treatment-resistant HPV-negative HNSCC.Experimental Design: A tumor...

Topics

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Comparative Genomic Hybridization
Exome Sequencing
Head and Neck Neoplasms
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Positron-Emission Tomography

Precision Medicine

RNA, Small Interfering

Tomography, X-Ray Computed

Source

Open in PubMed Open full text

Identifiers

PMID: 29599409
DOI: 10.1158/1078-0432.CCR-17-1339
PMCID: PMC6004257

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WEE1

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