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Article

Pannexin-1 is blocked by its C-terminus through a delocalized non-specific interaction surface.

PloS one - 1 Jan 2014

Dourado Michelle, Wong Evera, Hackos David H

Abstract excerpt

The Pannexin-1 (Panx1) channel is known to become activated under a variety of physiological conditions resulting in the release of medium-sized molecules such as ATP and amino acids from the cell. The detailed molecular mechanism of activation of the channel resulting in the opening of the Pannexin pore is poorly understood. The best-studied gating mechanism is caspase-3/7-mediated cleavage and truncation of the...

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Identifiers

PMID: 24911976
DOI: 10.1371/journal.pone.0099596
PMCID: PMC4049774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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