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Article

Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.

The Journal of clinical investigation - 1 Feb 2010

Morris John P, Cano David A, Sekine Shigeki, Wang Sam C, Hebrok Matthias

Abstract excerpt

Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient reactivation of pathways involved in embryonic pancreatic development. In contras...

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Identifiers

PMID: 20071774
DOI: 10.1172/JCI40045
PMCID: PMC2810083

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20071774-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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