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Article

Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk.

Clinical colorectal cancer - 1 Jun 2018

Mucha Bartosz, Pytel Dariusz, Markiewicz Lukasz, Cuchra Magda, Szymczak Izabela, Przybylowska-Sygut Karolina, Dziki Adam, Majsterek Ireneusz, Dziki Lukasz

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is leading malignant tumors to occur mainly in industrialized countries, where it exhibits one of the highest mortality rates. Up to 80% of all CRCs characterize a chromosomal instability (CIN) phenotype. The main challenge faced by scientist is to reveal the mechanism of CIN development. An often proposed model is defects in DNA repair in terms of efficiency and genetic...

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Source

Identifiers

PMID: 29793654
DOI: 10.1016/j.clcc.2016.10.001

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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