Article
[Repair of DNA damage using nucleotide excision repair (NER)--relationship with cancer risk].
Postepy higieny i medycyny doswiadczalnej - 1 Jan 2002
Butkiewicz Dorota, Rusin Marek, Pawlas Małgorzata, Czarny Małgorzata, Chorazy Mieczysław
Abstract excerpt
DNA damage repair, responsible for maintaining the genome integrity, plays a central role in cancer biology. Individual DNA repair capacity is genetically determined. Inherited defect in nucleotide excision repair (NER) genes leads to three distinct and extremely rare disorders: xeroderma pigmentosum, associated with high risk of skin cancer, Cockayne syndrome, and trichothiodystrophy. The recently identified...
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