CD 57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI 3 kinase delta syndrome

Abstract excerpt

Abstract Premature T‐cell immunosenescence with CD57+ CD8+ T‐cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical senescent T‐cell population seen in adult individuals or identifies a distinct population in APDS, we compared CD57+ CD8+ T cells from mostly pediatric APDS...

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