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Article

Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK.

Aging cell - 1 Feb 2018

Callender Lauren A, Carroll Elizabeth C, Beal Robert W J, Chambers Emma S, Nourshargh Sussan, Akbar Arne N, Henson Sian M

Abstract excerpt

Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to this subset and contribute to age-associated inflammation. We found the CD8+ CD45RA+ CD27- EMRA subset to be the most heterogeneous, with a population...

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Identifiers

PMID: 29024417
DOI: 10.1111/acel.12675
PMCID: PMC5770853

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