Article
CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells.
European journal of immunology - 1 Mar 2020
Pangrazzi Luca, Reidla Jürgen, Carmona Arana José Antonio, Naismith Erin, Miggitsch Carina, Meryk Andreas, Keller Michael, Krause Adelheid Alma Nora, Melzer Franz Leonard, Trieb Klemens, Schirmer Michael, Grubeck-Loebenstein Beatrix, Weinberger Birgit
Abstract excerpt
After repeated antigen exposure, both memory and terminally differentiated cells can be generated within CD8+ T cells. Although, during their differentiation, activated CD8+ T cells may first lose CD28, and CD28- cells may eventually express CD57 as a subsequent step, a population of CD28+ CD57+ (DP) CD8+ T cells can be identified in the peripheral blood. How this population is distinct from CD28- CD57- (DN) CD8+...
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