Article
Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes.
Archives of gerontology and geriatrics - 1 Jan 2000
Onyema Oscar Okwudiri, Njemini Rose, Forti Louis Nuvagah, Bautmans Ivan, Aerts Joeri L, De Waele Marc, Mets Tony
Abstract excerpt
BACKGROUND: During organismal aging, human T-cells shift towards less functional phenotypes, often called senescent cells. As these cells have not been well characterized, we aimed to relate surface markers of human T-cell senescence with characteristics of in vitro cellular aging and to further characterize these cells. METHODS: We identified, by flow cytometry, subpopulations of CD8+ T-cells based on CD57 and...
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