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Article

Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults.

Immunology - 1 Apr 2015

Riddell Natalie E, Griffiths Stephen J, Rivino Laura, King David C B, Teo Guo H, Henson Sian M, Cantisan Sara, Solana Rafael, Kemeny David M, MacAry Paul A, Larbi Anis, Akbar Arne N

Abstract excerpt

Antigen-specific multifunctional T cells that secrete interferon-γ, interleukin-2 and tumour necrosis factor-α simultaneously after activation are important for the control of many infections. It is unclear if these CD8(+) T cells are at an early or late stage of differentiation and whether telomere erosion restricts their replicative capacity. We developed a multi-parameter flow cytometric method for...

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PMID: 25314332
DOI: 10.1111/imm.12409
PMCID: PMC4368162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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