Article

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers

2021-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Histone lysine-specfic methyltransferase 2 (KMT2A-D) proteins, alternatively called mixed lineage leukaemia (MLL1-4) proteins, mediate positive transcriptional memory. As the catalytic subunits of human COMPASS-like complexes, they methylate H3K4 at promoters and enhancers. KMT2A-D contain understudied highly conserved triplets and a quartet of plant homeodomains (PHDs). Here, we show that all c...

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Literature Corpus work: dacc5e33-cb5a-58db-8146-62597148a2d0
DOI: 10.1101/2021.10.15.462366

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