Article
Centrosome Linker-induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers.
Molecular cancer research : MCR - 1 Sept 2018
Remo Andrea, Manfrin Erminia, Parcesepe Pietro, Ferrarini Alberto, Han Hye Seung, Mickys Ugnius, Laudanna Carmelo, Simbolo Michele, Malanga Donatella, Oliveira Duarte Mendes, Baritono Elisabetta, Colangelo Tommaso, Sabatino Lina, Giuliani Jacopo, Molinari Enrico, Garonzi Marianna, Xumerle Luciano, Delledonne Massimo, Giordano Guido, Ghimenton Claudio, Lonardo Fortunato, D'angelo Fulvio, Grillo Federica, Mastracci Luca, Viglietto Giuseppe, Ceccarelli Michele, Colantuoni Vittorio, Scarpa Aldo, Pancione Massimo
Abstract excerpt
Centrosome anomalies contribute to tumorigenesis, but it remains unclear how they are generated in lethal cancer phenotypes. Here, it is demonstrated that human microsatellite instable (MSI) and BRAFV600E-mutant colorectal cancers with a lethal rhabdoid phenotype are characterized by inactivation of centrosomal functions. A splice site mutation that causes an unbalanced dosage of rootletin (CROCC), a centrosome...
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