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Article

Centriolar subdistal appendages promote double-strand break repair through homologous recombination.

EMBO reports - 9 Oct 2023

Rodríguez-Real Guillermo, Domínguez-Calvo Andrés, Prados-Carvajal Rosario, Bayona-Feliú Aleix, Gomes-Pereira Sonia, Balestra Fernando R, Huertas Pablo

Abstract excerpt

The centrosome is a cytoplasmic organelle with roles in microtubule organization that has also been proposed to act as a hub for cellular signaling. Some centrosomal components are required for full activation of the DNA damage response. However, whether the centrosome regulates specific DNA repair pathways is not known. Here, we show that centrosome presence is required to fully activate recombination,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37664992
DOI: 10.15252/embr.202256724
PMCID: PMC10561181

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